Ana Fernandez-Sesma
Icahn School of Medicine at Mount Sinaihttp://labs.icahn.mssm.edu/fernandez-sesma-lab/

“Immune modulation by dengue virus: feeling the STING”

Friday, October 28
2:00 PM
101 LSA

ABSTRACT: Dengue virus (DENV) can efficiently modulate innate immune responses in infected cells, such as dendritic cells, which facilitate the establishment of infection by this important human pathogen in the host. Our group studies the innate immune pathways that are induced after DENV infection in susceptible human primary cells and systems with special focus on viral sensing as well as antagonistic functions exerted by the viral proteins. I will discuss the different elements generated during DENV infection that can trigger innate immune pathways, such as the cGAS/STING pathways in infected cells. I will  also show recent results on the mechanisms by which the components of the NS2B3 DENV protease can induce the degradation of different innate immune factors, including cGAS and STING, resulting in inhibition of type I IFN responses in infected cells.